[BostonCard]

From Mass General Hospital:

https://advances.massgeneral.org/researc...eWRLIn0%3D

He concludes from the available studies that hydroxychloroquine is unlikely to be of dramatic benefit in patients infected with SARS-CoV-2 and certainly has the potential for harm, particularly when administered with azithromycin

and

https://advances.massgeneral.org/researc...eWRLIn0%3D

Although earlier anecdotal reports and poorly controlled clinical trials initially raised optimism about the drugs in treating SARS-CoV-2, the authors present mechanistic reasons why these drugs may actually fail. To start, recent studies use data from lab-cultured cells, not patients. This early research also overlooked the powerful immunosuppressive action of the drugs and the fact that they have failed in previous respiratory virus outbreaks, including influenza.

The authors infer that the drugs inhibit innate immune reactions critical to viral defense, as well as the generation of adaptive, cell-mediated immunity that is also necessary to control a virus like SARS-CoV-2.

BC

[BostonCard]

From Mass General Hospital:

https://advances.massgeneral.org/researc...eWRLIn0%3D

He concludes from the available studies that hydroxychloroquine is unlikely to be of dramatic benefit in patients infected with SARS-CoV-2 and certainly has the potential for harm, particularly when administered with azithromycin

and

https://advances.massgeneral.org/researc...eWRLIn0%3D

Although earlier anecdotal reports and poorly controlled clinical trials initially raised optimism about the drugs in treating SARS-CoV-2, the authors present mechanistic reasons why these drugs may actually fail. To start, recent studies use data from lab-cultured cells, not patients. This early research also overlooked the powerful immunosuppressive action of the drugs and the fact that they have failed in previous respiratory virus outbreaks, including influenza.

The authors infer that the drugs inhibit innate immune reactions critical to viral defense, as well as the generation of adaptive, cell-mediated immunity that is also necessary to control a virus like SARS-CoV-2.

BC