Possible challenge trials initial steps - Printable Version

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Possible challenge trials initial steps - M T - 08-14-2020

Reuters is reporting:

Quote:U.S. government scientists have begun efforts to manufacture a strain of the novel coronavirus that could be used in human challenge trials of vaccines, a controversial type of study in which healthy volunteers would be vaccinated and then intentionally infected with the virus, Reuters has learned.

“Should there be a need for human challenge studies to fully assess candidate vaccines or therapeutics for SARS-CoV-2, NIAID has begun investigations of the technical and ethical considerations of conducting human challenge studies,” the agency statement said.

That includes efforts to manufacture a suitable SARS-CoV-2 strain, draft a clinical protocol and identify resources that would be required to conduct such studies.

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RE: Possible challenge trials initial steps - BostonCard - 08-14-2020

Here's a discussion by an ethicist:

https://www.ama-assn.org/delivering-care/ethics/top-ethicist-makes-case-covid-19-vaccine-challenge-trials

Quote:Human challenge trials intentionally place human subjects in harm’s way, so it is imperative that care be taken about when and how they are conducted. One prominent medical ethicist says challenge trials for COVID-19 vaccines might be the way to go, given the enormous morbidity and mortality associated with the infectious disease caused by SARS-CoV-2.

BC

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